Logistic Discriminant Analysis in Diagnosing Prostate Cancer Based on Chained Equation_West China Medical Journal

Authors：

ZHANG Wei ¹ , YUAN Jiaying ¹ , LI Yongzhong ² , LI Mei ³ , GOU Zhongping ³ ,  FENG Ping. ³

1. Department of Epidemiology and Biostatistics, West China School of Public Health; 2. Department of Ultrasound, West China Hospital; 3. National Clinical Trials Agencies, West China Hospital; Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

FENG Ping., Email: zhangwei19880404@163.com

Keywords：

链式方程; 多重填补; 前列腺癌; Logistic判别

DOI：

DOI: 10.7507/1002-0179.20130064

Video：

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目的　应用基于链式方程的填补方法处理医学研究中的数据缺失，并以填补后完全数据构建联合指标的logistic判别函数，判断其在前列腺癌的预测诊断中的应用价值。方法　采用模拟研究，针对现实数据缺失情况模拟不同填补集结果，并以此对现实数据进行填补，以完整数据构建logistic判别，进行分析预测。结果　填补结果随着填补次数的增加而逐渐接近真实值并趋于稳定。联合年龄、血清前列腺特异性抗原值、血流阻力指数及经直肠前列腺超声检查指标的logistic判别分析结果的灵敏度为82.39%，特异度为74.86%。结论　联合指标分析可提高前列腺癌的诊断预测水平，以减轻患者穿刺痛苦。

Citation： ZHANG Wei,YUAN Jiaying,LI Yongzhong,LI Mei,GOU Zhongping,FENG Ping.. Logistic Discriminant Analysis in Diagnosing Prostate Cancer Based on Chained Equation. West China Medical Journal, 2013, 28(2): 200-203. doi: DOI: 10.7507/1002-0179.20130064 Copy

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1. 　Little RJA, Rubin DB. Statistical analysis with missing data (Wiley series in probability and mathematical statistics)[M]. New York: Wiley John & Sons, 1987: 209-214.
2. 　Graham JW. Missing data analysis: making it work in the real world[J]. Annu Rev Psychol, 2009, 60: 549-576.
3. 　White IR, Royston P, Wood AM. Multiple imputation using chained equations: issues and guidance for practice[J]. Stat Med, 2011, 30(4): 377-399.
4. 　Lee KJ, Carlin JB. Multiple imputation for missing data: fully conditional specification versus multivariate normal imputation[J]. Am J Epidemiol, 2010, 171(5): 624-632.
5. 　Van Buuren S, Boshuizen HC, Knook DL. Multiple imputation of missing blood pressure covariates in survival analysis[J]. Stat Med, 1999, 18(6): 681-694.
6. 　Van Buuren S. Multiple imputation of discrete and continuous data by fully conditional specification[J]. Stat Methods Med Res, 2007, 16(3): 219-242.
7. 　Azur MJ, Stuart EA, Frangakis C, et al. Multiple imputation by chained equations:what is it and how does it work? [J]. Int J Methods Psychiatr Res, 2011, 20(1): 40-49.
8. 　Graham JW, Olchowski AE, Gilreath TD. How many imputations are really needed? Some practical clarifications of multiple imputation theory[J]. Prev Sci, 2007, 8(3): 206-213.
9. 　孙颖浩. 我国前列腺癌的研究现状[J]. 中华泌尿外科杂志, 2004(2): 5-8.
10. 　Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013[J]. CA Cancer J Clin, 2013, 63(1): 11-30.
11. 　沈伟东, 查月琴, 王阿军, 等. 经直肠超声结合前列腺特异性抗原密度检测对前列腺癌的诊断价值[J]. 苏州大学学报(医学版), 2008, 28(5): 811-813.
12. 　刘东亮, 卢一平. PSA 及其分子形式与PSAD、PSAV、PSAT在前列腺癌早期诊断中的应用[J]. 华西医学, 2003, 18(4): 591-592.
13. 　何有华, 杨琰, 陈映鹤, 等. 前列腺内腺动脉血流阻力指数对评估良性前列腺梗阻的意义[J]. 中国中西医结合外科杂志, 2008, 14(4): 323-325.
14. 　李永忠, 李响, 曾浩, 等. 经直肠超声引导行会阴部穿刺前列腺活检的临床意义[J]. 华西医学, 2008, 94(5): 998-999.
15. 　Kökeny GP, Cerri GG, de Oliveira Cerri LM, et al. Correlations among prostatic biopsy results, transrectal ultrasound findings and PSA levels in diagnosing prostate adenocarcinoma[J]. Eur J Ultrasound, 2000, 12(2): 103-113.

West China Medical Journal

Logistic Discriminant Analysis in Diagnosing Prostate Cancer Based on Chained Equation

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